What is NMN (β-Nicotinamide Mononucleotide)

Nicotinamide mononucleotides are nucleotides derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of nicotinic acid, which can be used by humans to produce nicotinamide adenine dinucleotide (NADH). NADH is a cofactor in the internal processes of mitochondria, sirtuins (longevity proteins) and PARP, which are essential for human health .

What are the advantages of NMN from Shaanxi Creative Herb Biotechnology Co.,ltd

1.Intertek (Intertek Group) authoritative quality testing and certification.

If you use the NMN ingredient from other suppliers instead of Shaanxi Creative Herb Biotechnology Co,.Ltd, that would put the brand at great risk. Indeed, it will be questioned that 200mg of NMN at 80% purity from other manufacturers is the same as 160mg of NMN at 99.9% purity from Shaanxi Creative Herb Biotechnoloby Co.,ltd. But the crucial part is, what is this other 40mg of impurities? No one knows and there is a significant safety risk! We supply the purest NMN brand ingredients certified by Intertek, an international third party.

2. Lower temperature and humidity sensitivity, higher bioavailability, more advanced sustained release technology.We all know that commercially available NMNs are very absorbent and because their products are very temperature sensitive, they can be very difficult to store and can deteriorate if the temperature is slightly higher. However, Our NMN has been optimised by our team of experts, is much lessabsorbent and temperature sensitive, making it possible to store it indoors at room temperature.

NMN VS NAD+

1.Nicotinamide mononucleotide (NMN) is a precursor to NAD+, the cofactor of longevity proteins in the human body, so before we understand NMN, let's understand what NAD+ is.

NAD+ is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugars, fats and amino acids and participating in the synthesis of energy; it is also the only substrate for the enzymes consumed by coenzyme I (the only substrate for the DNA repair enzyme PARP, the only substrate

for the long lived protein Sirtuins, the only substrate for the cyclic ADP ribose synthase CD38/157).

NAD+ is involved in all aspects of the body's metabolism and is a key coenzyme, without which metabolism fails. From the perspective of NAD+ supplementation, the four precursors that can supplement the three metabolic cycles of NAD+ are niacin, tryptophan, nicotinamide and NMN. NMN can break the bottleneck of the NAMPT rate-limiting enzyme and can rapidly replenish NAD+ in the body, which is

the best ideal supplementation method.

However, the NAD+ molecules are relatively large and while it is difficult for directly supplemented NAD+ from outside to pass through the cell membrane and enter the cell interior, the NMN molecules easily pass through the cell membrane and enter the cell interior. Once inside the cell,

2 NMN molecules will combine together to form one NAD+ molecule.Therefore, regular intake of this substance can effectively increase its level in the body, thus helping humans to repair DNA damage and slow down the ageing process!

So what does NMN do ?

Studies have shown that NMN helps to prevent anaemia, which is caused by insufficient blood flow to any part of the body. Normally, the body protects itself from anaemia through ischaemic preconditioning (IPC). IPC stimulates SIRT1, an NAD+dependent sirtuin, which contributes to blood flow throughout the body. Because NMN activates SIRT1, it has the ability to mimic IPC and thus protects the heart

from anaemia and clogged arteries!

1.Promotes normal brain function and prevents neurological disorders

Obviously effective blood circulation is vital to overall health. Specifically, adequate blood flow is vital

to brain health. Without enough oxygenated blood reaching our brains, a wide range of disorders can

occur. Fortunately, NMN helps to ensure that this vital organ gets all the oxygen it needs. Mitochondrial malfunction is a known precursor to neurodegenerative diseases, such as Alzheimer's disease. Having healthy and active mitochondria can help ward off such diseases. Studies have shown that because

NMN increases NAD+, which raises the level of mitochondrial activity, it has the potential to be a

protective agent against neurodegenerative diseases.

2. Fighting obesity and diabetes

In modern society, no matter how healthy a person's diet is, the chances of suffering from obesity and diabetes are higher than ever before. In addition to foods containing negative nutritional value and industrial seed oils, highcalorie processed foods are more common than healthy alternatives!

Just as persistently elevated blood sugar and insulin levels can lead to diabetes, persistent overeating

can eventually lead to weight gain. Our metabolism is a welloiled machine, but unless we make sure

they are functioning properly, bad habits will eventually cause them to falter.

As the body has multiple metabolic pathways, many different components are involved in maintaining adequate metabolic health. One of these is facilitated by nicotinamide phosphate ribosyltransferase (NAMPT), an NAD+dependent enzyme that we mentioned before. in 2011, the ability of NMN supplementation to treat NAMPT deficiency in diabetic mice was tested. Researchers found that NMN stimulated NAD+ biosynthesis and increased NAD+ levels in the pancreas, liver and white adipose tissue. The pancreas is directly responsible for the secretion of insulin which controls blood glucose levels and we can assume that this will help prevent diabetes. NMN has been found to reduce the effects of underlying causes of diabetes, significantly improve glucose tolerance and help prevent diabetes and obesity.

How does this all happen?

The body synthesises NAD+ in two ways: through the de novo pathway or the recycling pathway. The

de novo pathway is essentially what its name implies, as it "creates new" nucleotides from larger precursor compounds. Tryptophan is an essential amino acid that produces NAD+ in this pathway. More relevant to us, however, is the recycling pathway. Here, NAD+ is made via nicotinamide or nicotinic acid, both of which are derived from NMN, which is also the main pathway in mammalian cells, so our bodies prefer to obtain NAD+ via this pathway.

Conclusion: Use NMN to rejuvenate yourself!

The physical burden of ageing can be very heavy. When the body's metabolism is slowing down, you

are more likely to feel aches and pains and have less energy than we would like to see. However, with

the current state of science, this is still inevitable. However, this does not mean that there is no way to

slow down this deterioration!

Most of the symptoms of ageing are directly related to the working state of the mitochondria.

Energetic people produce a lot of NAD+, and as we age, the body produces less and less of it. Without

it, our bodies produce less ATP, after which the body starts to experience a variety of diseases and

adverse symptoms. Longterm use of NMN results in increased genetic repair and reduced cellular

carcinogenesis; increased cellular energy levels and improved immunity; restored hair follicle cell

activity and no more hair loss and hair growth; increased vascular epidermal cell activity, increased

capillary growth, increased tissue nutrient supply and increased regenerative capacity, resulting in

muscle growth and improved skin; increased ATP, the energy molecule produced by aerobic mitochondrial respiration, resulting in increased energy and Increased metabolic capacity of anaerobic respirationleads to increased explosive power; increased production of the neurotransmitter dopamine leads to

improved mood, increased stress resistance and reduced or even eliminated smoking addiction; restoration of the molecular mechanism of the negative feedback loop of the biological clock restores the

body's normal circadian rhythm, leading to increased deep sleep; increased energy supply to nerve

cells, increased regenerative capacity and increased neurotransmitters lead to improved Alzheimer's

disease and memory Enhanced ......... and more.